Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Very preterm (28 to 32 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17127 R71771	Delteil - Beta-blockers, 2024	Very preterm birth (28-32 GW)	at least 1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: Only chronic indication (hypertension or cardiac)	1.94 [1.02;3.68]	10/421 617/142,505	627	421		ref
S17151 R71928	Al Khalaf - Beta-blockers (Controls unexposed, disease free), 2022	Very preterm birth (less than 32 weeks)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, disease free excluded	Adjustment: No Indications Antihypertensive: Only chronic hypertension indication	4.15 [3.29;5.24] ^C excluded (control group)	74/1,827 17,507/1,739,944	17,581	1,827		ref
S17148 R71905	Al Khalaf - Beta-blockers (Controls unexposed, sick), 2022	Very preterm birth (less than 32 weeks)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, sick	Adjustment: No Indications Antihypertensive: Only chronic hypertension indication	1.58 [1.21;2.07] ^C	74/1,827 203/7,809	277	1,827		ref
S13392 R54161	Ray - Beta-blockers, 2001	Preterm birth before 32 weeks gestation	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: Yes Indications Antihypertensive: Only chronic hypertension indication	4.00 [1.30;12.40]	15/144 5/247	20	144		ref
					Total	3 studies	1.81 [1.27;2.59]		924	2,392
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17151