Fluoxetine updated on 07-01-2025

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18251
R76599		 Suarez (Controls unexposed, discontinuers), 2022 Any Specific Neurodevelopmental Disorder (ASD, ADHD, language disorder, learning disorders, intellectual disability, Developmental Coordination Disorder) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.14 [1.00;1.29] 2,323/26,595   493/7,773 2,816 26,595
ref
S18252
R76607		 Suarez (Controls unexposed, general pop), 2022 Any Specific Neurodevelopmental Disorder (ASD, ADHD, language disorder, learning disorders, intellectual disability, Developmental Coordination Disorder) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.20 [1.15;1.26]
excluded (control group) 		2,328/26,659   134,536/2,984,014 136,864 26,659
ref
S10193
R37361		 Heikkinen, 2003 Abnormal neurologic development - Modified Gesell developmental schedules (at 1 year) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.90 [0.02;50.25] C 0/11   0/10 0 11
ref
Total 2 studies 1.14 [1.00;1.29] 2,816 26,606
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Suarez (Controls unexposed, discontinuers), 2022Suarez, 2022 1 1.14[1.00; 1.29]2,81626,595100%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Heikkinen, 2003Heikkinen, 2003 0.90[0.02; 50.25]0110%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.14[1.00; 1.29]2,81626,6060.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, discontinuers;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.14[1.00; 1.29]2,81626,6060%NASuarez (Controls unexposed, discontinuers), 2022 Heikkinen, 2003 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.02; 50.25]-11 -NAHeikkinen, 2003 1 unexposed, sickunexposed, sick 1.14[1.00; 1.29]2,81626,595 -NASuarez (Controls unexposed, discontinuers), 2022 1 Tags Adjustment   - No  - No 0.90[0.02; 50.25]-11 -NAHeikkinen, 2003 1   - Yes  - Yes 1.14[1.00; 1.29]2,81626,595 -NASuarez (Controls unexposed, discontinuers), 2022 1 Monotherapy   - no or not specified  - no or not specified 1.14[1.00; 1.29]2,81626,6060%NASuarez (Controls unexposed, discontinuers), 2022 Heikkinen, 2003 2 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.14[1.00; 1.29]2,81626,595 -NASuarez (Controls unexposed, discontinuers), 2022 1 All studiesAll studies 1.14[1.00; 1.29]2,81626,6060%NASuarez (Controls unexposed, discontinuers), 2022 Heikkinen, 2003 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18252

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[1.15; 1.26]136,86426,6700%NASuarez (Controls unexposed, general pop), 2022 Heikkinen, 2003 2 unexposed, sick controlsunexposed, sick controls 1.14[1.00; 1.29]2,81626,595 -NASuarez (Controls unexposed, discontinuers), 2022 10.510.01.0