Fluoxetine updated on 07-01-2025

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18235
R76483		 Laspro, 2024 Isolated Cleft Palate (ICD-10 code Q35 excluding Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.70 [1.45;1.98]
excluded (exposition period) 		164/-   5,695/- 5,859 -
ref
S7469
R22225		 Anderson, 2020 Cleft palate only 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.06 [0.57;1.95] -/-   0/- - -
ref
S7354
R21613		 Jordan, 2016 Cleft palate 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.33 [0.02;5.22] C
excluded (exposition period) 		0/2,601   298/506,155 298 2,601
ref
S6242
R16497		 Malm, 2011 Cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.03 [0.33;3.25] -/1,818   -/628,607 - 1,818
ref
S6157
R16125		 Louik, 2007 Cleft palate alone 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00 [0.30;3.50] 3/64   374/6,173 377 64
ref
Total 3 studies 1.04 [0.64;1.71] 377 1,882
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.06[0.57; 1.95]--65%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Malm, 2011Malm, 2011 1.03[0.33; 3.25]-1,81819%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 1.00[0.30; 3.50]3776416%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.04[0.64; 1.71]3771,8820.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.33; 3.23]-1,818 -NAMalm, 2011 1 case control studiescase control studies 1.05[0.60; 1.82]377640%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.64; 1.71]3771,8820%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.04[0.64; 1.71]3771,8820%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 1.03[0.33; 3.23]-1,818 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.06[0.57; 1.96]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00[0.29; 3.42]37764 -NALouik, 2007 1 All studiesAll studies 1.04[0.64; 1.71]3771,8820%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.64; 1.71]3771,8820%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0