Fluoxetine updated on 07-01-2025

Cleft lip with or without cleft palate

id	Study   Auto Laspro, 2024Anderson, 2020Jordan, 2016Malm, 2011Louik, 2007	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18235 R76479	Laspro, 2024	Any cleft lip (ICD 10 codes Q36 or Q37)	during pregnancy (anytime or not specified) excluded	nested case control	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	1.01 [0.83;1.22] excluded (exposition period)	105/-   6,134/-	6,239	-		ref
S7469 R22226	Anderson, 2020	Cleft lip w/without cleft palate	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.08 [0.68;1.73]	-/-   0/-	-	-		ref
S7354 R21612	Jordan, 2016	Cleft lip with or without palate	3 months or more before pregnancy or1st trimester excluded	retrospective cohort (registry)	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	0.69 [0.17;2.77] C excluded (exposition period)	2/2,601   563/506,155	565	2,601		ref
S6242 R16496	Malm, 2011	Cleft lip with or without cleft palate	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	0.48 [0.07;3.42]	-/1,818   -/628,607	-	1,818		ref
S6157 R16120	Louik, 2007	Cleft lip with or without cleft palate	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...)	1.80 [0.80;3.80]	11/72   693/6,492	704	72		ref
					Total	3 studies	1.19 [0.79;1.81]		704	1,890
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded