Fluoxetine updated on 07-01-2025

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7194
R20431		 Colvin, 2011 Ectopic pregnancy 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.12 [0.37;2.71] 5/394   1,483/119,840 1,488 394
ref
S6733
R19032		 Diav-Citrin, 2008 Ectopic pregnancy during pregnancy (anytime or not specified) excluded prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.25 [0.27;68.11] C
excluded (exposition period) 		1/346   1/1,467 2 346
ref
S15005
R61453		 Chambers, 1996 Ectopic pregnancy 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.99 [0.20;123.20] C 1/154   0/254 1 154
ref
Total 2 studies 1.28 [0.49;3.31] 1,489 548
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 1.12[0.37; 2.71]1,48839491%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Chambers, 1996Chambers, 1996 4.99[0.20; 123.20]11549%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.28[0.49; 3.31]1,4895480.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.49; 3.31]1,4895480%NAColvin, 2011 Chambers, 1996 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.28[0.49; 3.31]1,4895480%NAColvin, 2011 Chambers, 1996 2 Tags Adjustment   - No  - No 1.28[0.49; 3.31]1,4895480%NAColvin, 2011 Chambers, 1996 2 Monotherapy   - no or not specified  - no or not specified 4.99[0.20; 123.20]1154 -NAChambers, 1996 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.12[0.41; 3.03]1,488394 -NAColvin, 2011 1 All studiesAll studies 1.28[0.49; 3.31]1,4895480%NAColvin, 2011 Chambers, 1996 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.49; 3.31]1,4895480%NAColvin, 2011 Chambers, 1996 20.510.01.0