Fluoxetine updated on 07-01-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7469
R22230		 Anderson, 2020 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.04 [0.48;2.27] -/-   0/- - -
ref
S7349
R21454		 Wemakor, 2015 Ano-rectal atresia and stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.55 [0.60;10.91] 2/29   390/17,446 392 29
ref
S6157
R16128		 Louik, 2007 Anal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.40 [0.30;6.10] 2/63   213/6,012 215 63
ref
Total 3 studies 1.29 [0.69;2.41] 607 92
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.04[0.48; 2.27]--64%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 2.55[0.60; 10.91]3922918%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2007Louik, 2007 1.40[0.30; 6.10]2156317%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.29[0.69; 2.41]607920.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.29[0.69; 2.41]607920%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.29[0.69; 2.41]607920%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.29[0.69; 2.41]607920%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.31[0.61; 2.82]3922912%NAAnderson, 2020 Wemakor, 2015 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.40[0.31; 6.31]21563 -NALouik, 2007 1 All studiesAll studies 1.29[0.69; 2.41]607920%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.29[0.69; 2.41]607920%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 30.510.01.0