Fluoxetine updated on 07-01-2025

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7469
R22200		 Anderson, 2020 Transposition of the great arteries 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.63 [0.81;3.26] -/-   0/- - -
ref
S7349
R21462		 Wemakor, 2015 Transposition of great vessels (complete) 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.50 [0.03;8.28] C 0/27   615/17,671 615 27
ref
S6242
R16492		 Malm, 2011 Transposition of the great vessels 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.72 [0.05;11.63] C 0/1,818   238/628,607 238 1,818
ref
Total 3 studies 1.46 [0.76;2.82] 853 1,845
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.63[0.81; 3.26]--89%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 0.50[0.03; 8.28]615276%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 0.72[0.05; 11.63]2381,8186%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.46[0.76; 2.82]8531,8450.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.72[0.05; 11.63]2381,818 -NAMalm, 2011 1 case control studiescase control studies 1.52[0.77; 2.99]615270%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.46[0.76; 2.82]8531,8450%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 3 Tags Adjustment   - No  - No 0.61[0.08; 4.34]8531,8450%NAWemakor, 2015 Malm, 2011 2   - Yes  - Yes 1.63[0.81; 3.27]-- -NAAnderson, 2020 1 Monotherapy   - no or not specified  - no or not specified 0.72[0.05; 11.63]2381,818 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.52[0.77; 2.99]615270%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.46[0.76; 2.82]8531,8450%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.46[0.76; 2.82]8531,8450%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.510.01.0