Fluoxetine updated on 07-01-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7469
R22238		 Anderson, 2020 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.98 [0.48;2.01] -/-   0/- - -
ref
S7486
R22407		 Given, 2017 Gastroschisis (excluding diabetes and anti-epileptic medication exposed) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 3.15 [1.13;8.79] 4/104   -/- - 104
ref
Total 2 studies 1.65 [0.53;5.16] 0 104
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.98[0.48; 2.01]--55%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Given, 2017Given, 2017 3.15[1.13; 8.79]-10445%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 70% 1.65[0.53; 5.16]-1040.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.65[0.53; 5.16]-10470%NAAnderson, 2020 Given, 2017 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.65[0.53; 5.16]-10470%NAAnderson, 2020 Given, 2017 2 Tags Adjustment   - Yes  - Yes 1.65[0.53; 5.16]-10470%NAAnderson, 2020 Given, 2017 2 Monotherapy   - no or not specified  - no or not specified 3.15[1.13; 8.79]-104 -NAGiven, 2017 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.98[0.48; 2.01]-- -NAAnderson, 2020 1 All studiesAll studies 1.65[0.53; 5.16]-10470%NAAnderson, 2020 Given, 2017 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.65[0.53; 5.16]-10470%NAAnderson, 2020 Given, 2017 20.510.01.0