Fluoxetine updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7923
R23972		 Stephansson, 2013 Stillbirth (after 22 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.67 [1.21;2.31] C
excluded (exposition period) 		37/6,013   5,919/1,604,649 5,956 6,013
ref
S7194
R20417		 Colvin, 2011 Stillbirths during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.83 [0.21;3.35] -/371   612/94,561 - 371
ref
S6733
R19031		 Diav-Citrin, 2008 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.53 [0.07;4.24] C 1/346   8/1,467 9 346
ref
S15005
R61451		 Chambers, 1996 Stillbirth late pregnancy prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.73 [0.15;19.31] C 1/74   2/254 3 74
ref
Total 3 studies 0.85 [0.30;2.40] 12 791
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 0.83[0.21; 3.35]-37156%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 0.53[0.07; 4.24]934625%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Chambers, 1996Chambers, 1996 1.73[0.15; 19.31]37419%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.85[0.30; 2.40]127910.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.85[0.30; 2.40]127910%NAColvin, 2011 Diav-Citrin, 2008 Chambers, 1996 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.85[0.30; 2.40]127910%NAColvin, 2011 Diav-Citrin, 2008 Chambers, 1996 3 Tags Adjustment   - No  - No 0.85[0.30; 2.40]127910%NAColvin, 2011 Diav-Citrin, 2008 Chambers, 1996 3 Monotherapy   - no or not specified  - no or not specified 0.88[0.18; 4.24]124200%NADiav-Citrin, 2008 Chambers, 1996 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.83[0.21; 3.32]-371 -NAColvin, 2011 1 All studiesAll studies 0.85[0.30; 2.40]127910%NAColvin, 2011 Diav-Citrin, 2008 Chambers, 1996 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.85[0.30; 2.40]6157910%NAColvin, 2011 Diav-Citrin, 2008 Chambers, 1996 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Xing (Stillbirths)Xing (Stillbirths) 1.59[0.23; 10.88]39%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 0.85[0.30; 2.40]0%791----Colvin, 2011 Diav-Citrin, 2008 Chambers, 1996 30.510.01.0