Fluoxetine updated on 07-01-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18436
R78147		 Lee (Controls exposed to TCAs), 2025 Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score, during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.97 [0.78;1.21] C
excluded (control group) 		380/719   328/613 708 719
ref
S18415
R77842		 Lee (Controls unexposed, general pop), 2025 Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score, during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.55 [1.33;1.81] 380/719   161,405/463,440 161,785 719
ref
S7287
R21076		 Maschi, 2008 Neonatal complications during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.00 [0.12;8.59] C 1/32   6/192 7 32
ref
Total 2 studies 1.55 [1.33;1.80] 161,792 751
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.55[1.33; 1.81]161,78571999%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Maschi, 2008Maschi, 2008 1.00[0.12; 8.59]7321%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.55[1.33; 1.80]161,7927510.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.55[1.33; 1.80]161,7927510%NALee (Controls unexposed, general pop), 2025 Maschi, 2008 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.55[1.33; 1.80]161,7927510%NALee (Controls unexposed, general pop), 2025 Maschi, 2008 2 Tags Adjustment   - No  - No 1.00[0.12; 8.59]732 -NAMaschi, 2008 1   - Yes  - Yes 1.55[1.33; 1.81]161,785719 -NALee (Controls unexposed, general pop), 2025 1 MatchedMatched 1.00[0.12; 8.59]732 -NAMaschi, 2008 1 Monotherapy   - no or not specified  - no or not specified 1.00[0.12; 8.59]732 -NAMaschi, 2008 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.55[1.33; 1.81]161,785719 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 1.55[1.33; 1.80]161,7927510%NALee (Controls unexposed, general pop), 2025 Maschi, 2008 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18436

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.55[1.33; 1.80]161,7927510%NALee (Controls unexposed, general pop), 2025 Maschi, 2008 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.97[0.78; 1.21]708719 -NALee (Controls exposed to TCAs), 2025 10.510.01.0