Paroxetine updated on 07-01-2025

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7470
R22267		 Anderson, 2020 Cleft palate only 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.09 [0.49;2.43] -/-   0/- - -
ref
S8216
R25607		 Jordan, 2016 Cleft palate 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.79 [0.05;12.72] C
excluded (exposition period) 		0/1,069   298/506,155 298 1,069
ref
S6243
R16510		 Malm, 2011 Cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.65 [0.98;7.14] -/968   -/628,607 - 968
ref
S6160
R16181		 Louik, 2007 Cleft palate alone 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.50 [0.40;5.30] 3/33   374/6,204 377 33
ref
Total 3 studies 1.54 [0.88;2.70] 377 1,001
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.09[0.49; 2.43]--49%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Malm, 2011Malm, 2011 2.65[0.98; 7.14]-96832%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 1.50[0.40; 5.30]3773319%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.54[0.88; 2.70]3771,0010.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.65[0.98; 7.15]-968 -NAMalm, 2011 1 case control studiescase control studies 1.19[0.60; 2.35]377330%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.54[0.88; 2.70]3771,0010%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.54[0.88; 2.70]3771,0010%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 2.65[0.98; 7.15]-968 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.09[0.49; 2.43]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.50[0.41; 5.46]37733 -NALouik, 2007 1 All studiesAll studies 1.54[0.88; 2.70]3771,0010%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.54[0.88; 2.70]3771,0010%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Cleft palate)Reefhuis (Cleft palate) 1.30[0.70; 2.30]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT4 metaPregmetaPreg 1.54[0.88; 2.70]0%1,001----Anderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0