Paroxetine updated on 07-01-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7470
R22268		 Anderson, 2020 Cleft lip w/without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.96 [0.50;1.82] -/-   0/- - -
ref
S8216
R25606		 Jordan, 2016 Cleft lip with or without palate 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.84 [0.12;5.99] C
excluded (exposition period) 		1/1,069   563/506,155 564 1,069
ref
S6243
R16509		 Malm, 2011 Cleft lip with or without cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.91 [0.13;6.52] -/968   -/628,607 - 968
ref
S6160
R16176		 Louik, 2007 Cleft lip with or without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.20 [0.40;3.60] 4/34   700/6,530 704 34
ref
Total 3 studies 1.01 [0.59;1.72] 704 1,002
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.96[0.50; 1.82]--69%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Malm, 2011Malm, 2011 0.91[0.13; 6.52]-9687%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 1.20[0.40; 3.60]7043424%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.01[0.59; 1.72]7041,0020.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.13; 6.44]-968 -NAMalm, 2011 1 case control studiescase control studies 1.02[0.58; 1.77]704340%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.01[0.59; 1.72]7041,0020%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.01[0.59; 1.72]7041,0020%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 0.91[0.13; 6.44]-968 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.96[0.50; 1.83]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.20[0.40; 3.60]70434 -NALouik, 2007 1 All studiesAll studies 1.01[0.59; 1.72]7041,0020%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.01[0.59; 1.72]7041,0020%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0