Paroxetine updated on 07-01-2025

Ventricular septal defect

id	Study   Auto Anderson, 2020Wemakor, 2015Huybrechts (Controls unexposed, NOS), 2014Huybrechts (Controls unexposed, sick), 2014Jimenez-Solem (Controls unexposed, NOS), 2012Jimenez-Solem (Controls unexposed, sick), 2012Malm, 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S7470 R22254	Anderson, 2020	Ventricular septal defect (VSD) – perimembranous type	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.96 [1.03;3.74]	-/-   0/-	-	-		ref
S7350 R21489	Wemakor, 2015	Ventricular septal defect	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.90 [1.04;3.48]	18/45   6,149/23,205	6,167	45		ref
S6100 R15918	Huybrechts (Controls unexposed, NOS), 2014	Ventricular Septal Defect	1st trimester	cohort	unexposed (general population or NOS) excluded	Adjustment: No Monotherapy: no or not specified	1.09 [0.81;1.47] excluded (control group)	44/11,126   3,212/885,115	3,256	11,126		ref
S6101 R15922	Huybrechts (Controls unexposed, sick), 2014	Ventricular Septal Defect	1st trimester	cohort	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified	0.73 [0.49;1.08]	28/8,760   751/180,564	779	8,760		ref
S6017 R15552	Jimenez-Solem (Controls unexposed, NOS), 2012	Ventricular septal defects	1st trimester	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...)	1.13 [0.28;4.54] excluded (control group)	2/568   2,803/843,797	2,805	568		ref
S6022 R15620	Jimenez-Solem (Controls unexposed, sick), 2012	Ventricular septal defects	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	0.31 [0.07;1.45] C	2/568   9/806	11	568		ref
S6243 R16504	Malm, 2011	Ventricular septal defects	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	1.01 [0.54;1.88]	10/968   5,465/628,607	5,475	968		ref
					Total	5 studies	1.11 [0.66;1.87]		12,432	10,341
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 6017, 6100

Umbrella review (other published meta-analyses)