Paroxetine updated on 07-01-2025

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7350
R21479		 Wemakor, 2015 Club foot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.99 [1.44;6.21] 10/37   1,982/19,038 1,992 37
ref
S7906
R23943		 Yazdy, 2014 Club foot 1st trimester case control unexposed, disease free Adjustment: Yes Monotherapy: no or not specified 9.20 [0.70;484.60] 3/4   619/2,620 622 4
ref
S6160
R16180		 Louik, 2007 Clubfoot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 5.80 [2.60;12.80] 10/40   403/6,233 413 40
ref
Total 3 studies 4.14 [2.43;7.04] 3,027 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 2.99[1.44; 6.21]1,9923753%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yazdy, 2014Yazdy, 2014 9.20[0.70; 484.60]62243%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Louik, 2007Louik, 2007 5.80[2.60; 12.80]4134044%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 4.14[2.43; 7.04]3,027810.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 4.14[2.43; 7.04]3,027810%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.14[2.43; 7.04]3,027810%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 4.14[2.43; 7.04]3,027810%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 9.20[0.35; 242.06]6224 -NAYazdy, 2014 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.99[1.44; 6.21]1,99237 -NAWemakor, 2015 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 5.80[2.61; 12.87]41340 -NALouik, 2007 1 All studiesAll studies 4.14[2.43; 7.04]3,027810%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.14[2.43; 7.04]3,027810%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Chen (Clubfoot)Chen (Clubfoot) 4.26[2.52; 7.19]4 %-Wwhatever (meta-analysis)T11st trimesterstudies TTT3 metaPregmetaPreg 4.14[2.43; 7.04]0%81----Wemakor, 2015 Yazdy, 2014 Louik, 2007 30.510.01.0