Paroxetine updated on 07-01-2025

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7350
R21483		 Wemakor, 2015 Limb reduction 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.86 [0.56;6.17] 2/29   782/17,838 784 29
ref
S6160
R16186		 Louik, 2007 Limb-reduction defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00 [0.10;8.30] 1/31   192/6,022 193 31
ref
Total 2 studies 1.61 [0.56;4.63] 977 60
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 1.86[0.56; 6.17]7842977%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2007Louik, 2007 1.00[0.10; 8.30]1933123%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.61[0.56; 4.63]977600.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.61[0.56; 4.63]977600%NAWemakor, 2015 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.56; 4.63]977600%NAWemakor, 2015 Louik, 2007 2 Tags Adjustment   - No  - No 1.86[0.56; 6.17]78429 -NAWemakor, 2015 1   - Yes  - Yes 1.00[0.11; 9.11]19331 -NALouik, 2007 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.86[0.56; 6.17]78429 -NAWemakor, 2015 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00[0.11; 9.11]19331 -NALouik, 2007 1 All studiesAll studies 1.61[0.56; 4.63]977600%NAWemakor, 2015 Louik, 2007 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.56; 4.63]977600%NAWemakor, 2015 Louik, 2007 20.510.01.0