Paroxetine updated on 07-01-2025

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7470
R22260		 Anderson, 2020 Spina bifida 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.67 [0.21;2.18] -/-   0/- - -
ref
S8216
R25590		 Jordan, 2016 Spina Bifida 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.12 [1.02;16.61] C
excluded (exposition period) 		2/1,069   230/506,155 232 1,069
ref
S7228
R20753		 Davis, 2007 Spina bifida 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.63 [0.28;76.13] C 0/182   29/49,654 29 182
ref
Total 2 studies 1.14 [0.21;6.20] 29 182
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.67[0.21; 2.18]--73%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Davis, 2007Davis, 2007 4.63[0.28; 76.13]2918227%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 36% 1.14[0.21; 6.20]291820.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.63[0.28; 76.13]29182 -NADavis, 2007 1 case control studiescase control studies 0.67[0.21; 2.16]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[0.21; 6.20]2918236%NAAnderson, 2020 Davis, 2007 2 Tags Adjustment   - No  - No 4.63[0.28; 76.13]29182 -NADavis, 2007 1   - Yes  - Yes 0.67[0.21; 2.16]-- -NAAnderson, 2020 1 Monotherapy   - no or not specified  - no or not specified 4.63[0.28; 76.13]29182 -NADavis, 2007 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.67[0.21; 2.16]-- -NAAnderson, 2020 1 All studiesAll studies 1.14[0.21; 6.20]2918236%NAAnderson, 2020 Davis, 2007 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[0.21; 6.20]2918236%NAAnderson, 2020 Davis, 2007 20.510.01.0