Paroxetine updated on 07-01-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7470
R22280		 Anderson, 2020 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.91 [1.56;5.44] -/-   0/- - -
ref
S7350
R21495		 Wemakor, 2015 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.75 [0.05;12.35] C 0/27   413/17,469 413 27
ref
Total 2 studies 2.73 [1.48;5.02] 413 27
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 2.91[1.56; 5.44]--95%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 0.75[0.05; 12.35]413275%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.73[1.48; 5.02]413270.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.73[1.48; 5.02]413270%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.73[1.48; 5.02]413270%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 0.75[0.05; 12.35]41327 -NAWemakor, 2015 1   - Yes  - Yes 2.91[1.56; 5.43]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.73[1.48; 5.02]413270%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 2.73[1.48; 5.02]413270%NAAnderson, 2020 Wemakor, 2015 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.73[1.48; 5.02]413270%NAAnderson, 2020 Wemakor, 2015 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Gastroschisis)Reefhuis (Gastroschisis) 2.50[1.20; 4.80]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 2.73[1.48; 5.02]0%27----Anderson, 2020 Wemakor, 2015 20.510.01.0