Venlafaxine updated on 07-01-2025

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11742
R43099		 Hanley, 2016 Postpartum hemorrhage late pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.64 [1.38;1.96] 154/1,390   21,745/310,813 21,899 1,390
ref
S11740
R43096		 Palmsten b, 2013 Postpartum hemorrhage (ICD-9 code for 666.x) late pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified 2.24 [1.69;2.97] 46/763   1,896/69,044 1,942 763
ref
Total 2 studies 1.88 [1.39;2.54] 23,841 2,153
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hanley, 2016Hanley, 2016 1.64[1.38; 1.96]21,8991,39057%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Palmsten b, 2013Palmsten b, 2013 2.24[1.69; 2.97]1,94276343%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 70% 1.88[1.39; 2.54]23,8412,1530.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.88[1.39; 2.54]23,8412,15370%NAHanley, 2016 Palmsten b, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.64[1.38; 1.95]21,8991,390 -NAHanley, 2016 1 unexposed, sickunexposed, sick 2.24[1.69; 2.97]1,942763 -NAPalmsten b, 2013 1 Tags Adjustment   - Yes  - Yes 1.88[1.39; 2.54]23,8412,15370%NAHanley, 2016 Palmsten b, 2013 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.88[1.39; 2.54]23,8412,15370%NAHanley, 2016 Palmsten b, 2013 2 Unexposed sick   - old history of illness/treatment (> ...  - old history of illness/treatment (> 12 months before pregnancy) or not specified 2.24[1.69; 2.97]1,942763 -NAPalmsten b, 2013 1 All studiesAll studies 1.88[1.39; 2.54]23,8412,15370%NAHanley, 2016 Palmsten b, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.64[1.38; 1.95]21,8991,390 -NAHanley, 2016 1 unexposed, sick controlsunexposed, sick controls 2.24[1.69; 2.97]1,942763 -NAPalmsten b, 2013 10.510.01.0