Venlafaxine updated on 07-01-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18324
R77190		 Laspro, 2024 Any cleft lip (ICD 10 codes Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.58 [1.24;2.02]
excluded (exposition period) 		65/-   6,174/- 6,239 -
ref
S11773
R43296		 Anderson, 2020 Cleft lip w/without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.98 [0.95;4.12] -/-   0/- - -
ref
Total 1 studies 1.98 [0.95;4.12] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.98[0.95; 4.12]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.98[0.95; 4.12]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.98[0.95; 4.12]-- -NAAnderson, 2020 1 Tags Adjustment   - Yes  - Yes 1.98[0.95; 4.12]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.98[0.95; 4.12]-- -NAAnderson, 2020 1 All studiesAll studies 1.98[0.95; 4.12]-- -NAAnderson, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.98[0.95; 4.12]-- -NAAnderson, 2020 10.510.01.0