Venlafaxine updated on 07-01-2025

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11773
R43299		 Anderson, 2020 Hypospadias, 2nd or 3rd degree 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.60 [0.61;4.18] -/-   0/- - -
ref
S11689
R42982		 Furu, 2015 Hypospadias 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.13 [0.54;2.38] 7/2,763   4,526/2,266,875 4,533 2,763
ref
Total 2 studies 1.29 [0.71;2.31] 4,533 2,763
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.60[0.61; 4.18]--37%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Furu, 2015Furu, 2015 1.13[0.54; 2.38]4,5332,76363%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.29[0.71; 2.31]4,5332,7630.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.13[0.54; 2.37]4,5332,763 -NAFuru, 2015 1 case control studiescase control studies 1.60[0.61; 4.19]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.29[0.71; 2.31]4,5332,7630%NAAnderson, 2020 Furu, 2015 2 Tags Adjustment   - Yes  - Yes 1.29[0.71; 2.31]4,5332,7630%NAAnderson, 2020 Furu, 2015 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.29[0.71; 2.31]4,5332,7630%NAAnderson, 2020 Furu, 2015 2 All studiesAll studies 1.29[0.71; 2.31]4,5332,7630%NAAnderson, 2020 Furu, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.29[0.71; 2.31]4,5332,7630%NAAnderson, 2020 Furu, 2015 20.510.01.0