Venlafaxine updated on 07-01-2025

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11773
R43287		 Anderson, 2020 Septal defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.27 [1.20;4.26] -/-   0/- - -
ref
S11698
R43048		 Bérard b (Controls unexposed, sick), 2017 Ventricular/atrial septal defect 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.73 [0.39;1.39] -/738   -/14,847 - 738
ref
S11689
R42981		 Furu, 2015 Atrial and ventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.10 [0.73;1.64] 25/2,763   17,503/2,266,875 17,528 2,763
ref
Total 3 studies 1.21 [0.68;2.14] 17,528 3,501
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 2.27[1.20; 4.26]--30%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Bérard b (Controls unexposed, sick), 2017Bérard b, 2017 1 0.73[0.39; 1.39]-73830%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Furu, 2015Furu, 2015 1.10[0.73; 1.64]17,5282,76339%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 69% 1.21[0.68; 2.14]17,5283,5010.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.67; 1.40]17,5283,50112%NABérard b (Controls unexposed, sick), 2017 Furu, 2015 2 case control studiescase control studies 2.27[1.20; 4.28]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.51[0.75; 3.06]17,5282,76372%NAAnderson, 2020 Furu, 2015 2 unexposed, sickunexposed, sick 0.73[0.39; 1.38]-738 -NABérard b (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 1.21[0.68; 2.14]17,5283,50169%NAAnderson, 2020 Bérard b (Controls unexposed, sick), 2017 Furu, 2015 3 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.21[0.68; 2.14]17,5283,50169%NAAnderson, 2020 Bérard b (Controls unexposed, sick), 2017 Furu, 2015 3 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.73[0.39; 1.38]-738 -NABérard b (Controls unexposed, sick), 2017 1 All studiesAll studies 1.21[0.68; 2.14]17,5283,50169%NAAnderson, 2020 Bérard b (Controls unexposed, sick), 2017 Furu, 2015 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.51[0.75; 3.06]17,5282,76372%NAAnderson, 2020 Furu, 2015 2 unexposed, sick controlsunexposed, sick controls 0.73[0.39; 1.38]-738 -NABérard b (Controls unexposed, sick), 2017 10.510.01.0