Venlafaxine updated on 07-01-2025

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11834
R43444		 Kolding (Controls unexposed, disease free), 2021 Severe cardiac malformations (cardiac malformations that end in miscarriage, termination, stillbirth, postnatal death or cardiac surgery <1 year of birth) 1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes Monotherapy: no or not specified 2.13 [0.89;5.13]
excluded (control group) 		5/847   915/346,227 920 847
ref
S11835
R43447		 Kolding (Controls unexposed, sick), 2021 Severe cardiac malformations (cardiac malformations that end in miscarriage, termination, stillbirth, postnatal death or cardiac surgery <1 year of birth) 1st trimester population based cohort retrospective unexposed, sick Adjustment: No Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.78 [0.67;4.70] 5/847   21/6,305 26 847
ref
Total 1 studies 1.78 [0.67;4.71] 26 847
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kolding (Controls unexposed, sick), 2021Kolding, 2021 1 1.78[0.67; 4.70]268470%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 1 Monotherapy   - no or not specified  - no or not specified 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 1 All studiesAll studies 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11834

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.13[0.89; 5.11]920847 -NAKolding (Controls unexposed, disease free), 2021 1 unexposed, sick controlsunexposed, sick controls 1.78[0.67; 4.71]26847 -NAKolding (Controls unexposed, sick), 2021 10.510.01.0