Venlafaxine updated on 07-01-2025

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11698
R43045		 Bérard b (Controls unexposed, sick), 2017 Urinary system malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.43 [0.75;2.73] -/738   -/14,847 - 738
ref
Total 1 studies 1.43 [0.75;2.73] 0 738
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard b (Controls unexposed, sick), 2017Bérard b, 2017 1 1.43[0.75; 2.73]-7380%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 1 All studiesAll studies 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.43[0.75; 2.73]-738 -NABérard b (Controls unexposed, sick), 2017 10.510.01.0