Venlafaxine updated on 07-01-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11775
R43318		 Richardson, 2019 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.02 [0.60;1.68] 21/281   103/1,405 124 281
ref
S11792
R43390		 Ozturk, 2016 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.39 [0.68;16.78] C 2/13   14/275 16 13
ref
S11777
R43336		 Te Winkel, 2016 Elective terminations of pregnancy (ETOPs) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.36 [1.46;3.82] C 57/732   25/724 82 732
ref
S11692
R42993		 Kieler, 2015 Elective termination of pregnancy (at 12–23 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.60 [1.80;3.90] -/-   14,911/- - -
ref
Total 4 studies 1.97 [1.19;3.26] 222 1,026
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Richardson, 2019Richardson, 2019 1.02[0.60; 1.68]12428129%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Ozturk, 2016Ozturk, 2016 3.39[0.68; 16.78]16138%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Te Winkel, 2016Te Winkel, 2016 2.36[1.46; 3.82]8273230%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Kieler, 2015Kieler, 2015 2.60[1.80; 3.90]--33%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 67% 1.97[1.19; 3.26]2221,0260.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.75[0.86; 3.55]2221,02668%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 3 case control studiescase control studies 2.60[1.77; 3.83]-- -NAKieler, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.97[1.19; 3.26]2221,02667%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 Kieler, 2015 4 Tags Adjustment   - No  - No 1.75[0.86; 3.55]2221,02668%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 3   - Yes  - Yes 2.60[1.77; 3.83]-- -NAKieler, 2015 1 MatchedMatched 1.66[0.66; 4.14]12428188%NARichardson, 2019 Kieler, 2015 2 Monotherapy   - no or not specified  - no or not specified 1.75[0.86; 3.55]2221,02668%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 3   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.60[1.77; 3.83]-- -NAKieler, 2015 1 All studiesAll studies 1.97[1.19; 3.26]2221,02667%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 Kieler, 2015 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.92.60.9790.000Richardson, 2019Ozturk, 2016Te Winkel, 2016Kieler, 2015

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.97[1.19; 3.26]15,1241,02667%NARichardson, 2019 Ozturk, 2016 Te Winkel, 2016 Kieler, 2015 40.510.01.0