Venlafaxine updated on 07-01-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18311
R77111		 Martin, 2024 Small for gestational age (SGA, defined as those with a birth weight in the lowest 10 percentiles for gestational age (<10th percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.91 [0.83;1.00] 564/5,495   229,066/2,408,707 229,630 5,495
ref
S11775
R43322		 Richardson, 2019 Small for gestational age at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: no or not specified 1.03 [0.51;1.89] 12/133   65/722 77 133
ref
Total 2 studies 0.91 [0.83;1.00] 229,707 5,628
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Martin, 2024Martin, 2024 0.91[0.83; 1.00]229,6305,49598%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Richardson, 2019Richardson, 2019 1.03[0.51; 1.89]771332%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.91[0.83; 1.00]229,7075,6280.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.83; 1.00]229,7075,6280%NAMartin, 2024 Richardson, 2019 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.91[0.83; 1.00]229,7075,6280%NAMartin, 2024 Richardson, 2019 2 Tags Adjustment   - Yes  - Yes 0.91[0.83; 1.00]229,7075,6280%NAMartin, 2024 Richardson, 2019 2 MatchedMatched 1.03[0.53; 1.99]77133 -NARichardson, 2019 1 Monotherapy   - no or not specified  - no or not specified 1.03[0.53; 1.99]77133 -NARichardson, 2019 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.91[0.83; 1.00]229,6305,495 -NAMartin, 2024 1 All studiesAll studies 0.91[0.83; 1.00]229,7075,6280%NAMartin, 2024 Richardson, 2019 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.83; 1.00]229,7075,6280%NAMartin, 2024 Richardson, 2019 20.510.01.0