Acetaminophen (Paracetamol) updated on 09-20-2024

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16647
R69892		 Sznajder, 2022 Neonatal intensive care unit (NICU) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Paracetamol use: maternal ITW/questionnaires during pregnancy 1.37 [0.95;1.98] C 60/1,011   62/1,411 122 1,011
ref
S18513
R78660		 Zafeiri, 2022 Admitted to neonatal unit during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.45 [1.38;1.53] 3,956/20,298   11,011/73,389 14,967 20,298
ref
Total 2 studies 1.45 [1.38;1.52] 15,089 21,309
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sznajder, 2022Sznajder, 2022 1.37[0.95; 1.98]1221,0112%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Zafeiri, 2022Zafeiri, 2022 1.45[1.38; 1.53]14,96720,29898%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.45[1.38; 1.52]15,08921,3090.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.45[1.38; 1.52]15,08921,3090%NASznajder, 2022 Zafeiri, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.45[1.38; 1.52]15,08921,3090%NASznajder, 2022 Zafeiri, 2022 2 Tags Adjustment   - No  - No 1.37[0.95; 1.98]1221,011 -NASznajder, 2022 1   - Yes  - Yes 1.45[1.38; 1.53]14,96720,298 -NAZafeiri, 2022 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.45[1.38; 1.52]15,08921,3090%NASznajder, 2022 Zafeiri, 2022 2 All studiesAll studies 1.45[1.38; 1.52]15,08921,3090%NASznajder, 2022 Zafeiri, 2022 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.45[1.38; 1.52]15,08921,3090%NASznajder, 2022 Zafeiri, 2022 20.510.01.0