Acetaminophen (Paracetamol) updated on 09-20-2024

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18577
R78932		 Killion, 2022 Preeclampsia and pregnancy-induced hypertension - Cumulative acetaminophen use at 20 weeks 5th quintile early pregnancy prospective cohort unexposed, sick Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.62 [1.10;2.40] 43/-   47/473 90 -
ref
S18618
R79105		 Rebordosa, 2010 Preeclampsia 'definitive' (in maternal interview and registry ICD-10 diagnosis of preeclampsia (O14–O15)) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.08 [0.95;1.22] 366/19,630   747/44,203 1,113 19,630
ref
Total 2 studies 1.27 [0.86;1.87] 1,203 19,630
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Killion, 2022Killion, 2022 1.62[1.10; 2.40]90-39%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Rebordosa, 2010Rebordosa, 2010 1.08[0.95; 1.22]1,11319,63061%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 73% 1.27[0.86; 1.87]1,20319,6300.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[0.86; 1.87]1,20319,63073%NAKillion, 2022 Rebordosa, 2010 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.95; 1.22]1,11319,630 -NARebordosa, 2010 1 unexposed, sickunexposed, sick 1.62[1.10; 2.39]90- -NAKillion, 2022 1 Tags Adjustment   - Yes  - Yes 1.27[0.86; 1.87]1,20319,63073%NAKillion, 2022 Rebordosa, 2010 2 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.27[0.86; 1.87]1,20319,63073%NAKillion, 2022 Rebordosa, 2010 2 All studiesAll studies 1.27[0.86; 1.87]1,20319,63073%NAKillion, 2022 Rebordosa, 2010 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.95; 1.22]1,11319,630 -NARebordosa, 2010 1 unexposed, sick controlsunexposed, sick controls 1.62[1.10; 2.39]90- -NAKillion, 2022 10.510.01.0