Acetaminophen (Paracetamol) updated on 09-20-2024

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18501
R79034		 Feldkamp, 2010 Cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.13 [0.94;1.36] 296/2,193   274/2,411 570 2,193
ref
S18505
R78750		 Rebordosa a, 2008 Cleft palate 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.17 [0.80;1.72] 44/26,424   84/61,718 128 26,424
ref
S18778
R79902		 Puho, 2007 Posterior cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy Paracetamol use: prescription or medical files 3.70 [1.10;12.00] 3/52   598/38,700 601 52
ref
Total 3 studies 1.23 [0.90;1.70] 1,299 28,669
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 1.13[0.94; 1.36]5702,19358%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Rebordosa a, 2008Rebordosa a, 2008 1.17[0.80; 1.72]12826,42435%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Puho, 2007Puho, 2007 3.70[1.10; 12.00]601526%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 46% 1.23[0.90; 1.70]1,29928,6690.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.17[0.80; 1.72]12826,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.75[0.57; 5.39]1,1712,24573%NAFeldkamp, 2010 Puho, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.23[0.90; 1.70]1,29928,66946%NAFeldkamp, 2010 Rebordosa a, 2008 Puho, 2007 3 Tags Adjustment   - Yes  - Yes 1.23[0.90; 1.70]1,29928,66946%NAFeldkamp, 2010 Rebordosa a, 2008 Puho, 2007 3 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.13[0.94; 1.36]5702,193 -NAFeldkamp, 2010 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.80[0.60; 5.36]72926,47669%NARebordosa a, 2008 Puho, 2007 2   - prescription or medical files  - prescription or medical files 3.70[1.12; 12.22]60152 -NAPuho, 2007 1 All studiesAll studies 1.23[0.90; 1.70]1,29928,66946%NAFeldkamp, 2010 Rebordosa a, 2008 Puho, 2007 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.90; 1.70]1,29928,66946%NAFeldkamp, 2010 Rebordosa a, 2008 Puho, 2007 30.510.01.0