Acetaminophen (Paracetamol) updated on 09-20-2024

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18501
R79033		 Feldkamp, 2010 Cleft lip with and without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.97 [0.84;1.11] 519/2,416   591/2,728 1,110 2,416
ref
S18778
R79903		 Puho, 2007 Cleft lip with or without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy Paracetamol use: prescription or medical files 2.10 [0.90;5.00] 6/56   1,368/39,469 1,374 56
ref
Total 2 studies 1.27 [0.62;2.60] 2,484 2,472
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 0.97[0.84; 1.11]1,1102,41666%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Puho, 2007Puho, 2007 2.10[0.90; 5.00]1,3745634%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 67% 1.27[0.62; 2.60]2,4842,4720.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.27[0.62; 2.60]2,4842,47267%NAFeldkamp, 2010 Puho, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[0.62; 2.60]2,4842,47267%NAFeldkamp, 2010 Puho, 2007 2 Tags Adjustment   - Yes  - Yes 1.27[0.62; 2.60]2,4842,47267%NAFeldkamp, 2010 Puho, 2007 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.97[0.84; 1.12]1,1102,416 -NAFeldkamp, 2010 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 2.10[0.89; 4.95]1,37456 -NAPuho, 2007 1   - prescription or medical files  - prescription or medical files 2.10[0.89; 4.95]1,37456 -NAPuho, 2007 1 All studiesAll studies 1.27[0.62; 2.60]2,4842,47267%NAFeldkamp, 2010 Puho, 2007 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[0.62; 2.60]2,4842,47267%NAFeldkamp, 2010 Puho, 2007 20.510.01.0