Acetaminophen (Paracetamol) updated on 09-20-2024

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18775
R79885		 Werler, 2014 Isolated Clubfoot without first-degree history 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.98 [0.79;1.22] 220/1,009   350/1,583 570 1,009
ref
Total 1 studies 0.98 [0.79;1.22] 570 1,009
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Werler, 2014Werler, 2014 0.98[0.79; 1.22]5701,0090%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 1 Tags Adjustment   - Yes  - Yes 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 1 All studiesAll studies 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.98[0.79; 1.22]5701,009 -NAWerler, 2014 10.510.01.0