Acetaminophen (Paracetamol) updated on 09-20-2024

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18513
R78666		 Zafeiri, 2022 Hypospadias (only males included) during pregnancy (anytime or not specified) excluded retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.07 [0.84;1.37]
excluded (exposition period) 		96/12,354   259/54,866 355 12,354
ref
S18599
R79073		 Lind, 2013 Isolated Second- or Third-Degree Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.90 [0.80;1.10] 895/3,402   568/2,366 1,463 3,402
ref
S18585
R78983		 Snijder, 2012 Hypospadias - Cumulative prevalence over 30 months follow up 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 2.24 [0.60;8.32] 3/-   -/- - -
ref
S18505
R78760		 Rebordosa a, 2008 Hypospadias 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.01 [0.76;1.33] 80/26,424   181/61,718 261 26,424
ref
Total 3 studies 0.94 [0.80;1.10] 1,724 29,826
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lind, 2013Lind, 2013 0.90[0.80; 1.10]1,4633,40270%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Snijder, 2012Snijder, 2012 2.24[0.60; 8.32]--1%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Rebordosa a, 2008Rebordosa a, 2008 1.01[0.76; 1.33]26126,42428%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 9% 0.94[0.80; 1.10]1,72429,8260.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.65; 2.04]26126,42426%NASnijder, 2012 Rebordosa a, 2008 2 case control studiescase control studies 0.90[0.77; 1.06]1,4633,402 -NALind, 2013 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.80; 1.10]1,72429,8269%NALind, 2013 Snijder, 2012 Rebordosa a, 2008 3 Tags Adjustment   - Yes  - Yes 0.94[0.80; 1.10]1,72429,8269%NALind, 2013 Snijder, 2012 Rebordosa a, 2008 3 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.90[0.77; 1.06]1,4633,402 -NALind, 2013 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.15[0.65; 2.04]26126,42426%NASnijder, 2012 Rebordosa a, 2008 2 All studiesAll studies 0.94[0.80; 1.10]1,72429,8269%NALind, 2013 Snijder, 2012 Rebordosa a, 2008 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.80; 1.10]1,72429,8269%NALind, 2013 Snijder, 2012 Rebordosa a, 2008 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Eletri (Hypospadias)Eletri (Hypospadias) 1.02[0.89; 1.17]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 0.94[0.80; 1.10]9%29,826----Lind, 2013 Snijder, 2012 Rebordosa a, 2008 30.510.01.0