Acetaminophen (Paracetamol) updated on 09-20-2024

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18513
R78664		 Zafeiri, 2022 Neural tube defects during pregnancy (anytime or not specified) excluded retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.21 [0.71;2.06]
excluded (exposition period) 		22/24,099   50/107,143 72 24,099
ref
S18501
R79019		 Feldkamp, 2010 Neural tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.10 [0.92;1.30] 339/2,295   371/2,558 710 2,295
ref
S18639
R79216		 Pérez-Molina, 2002 High neural tube defects (anencephaly, encephalocele, myelocele, meningocele, or myelomeningocele occurred at or above the 11th thoracic vertebra (T11)) 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: maternal ITW/questionnaires after pregnancy 5.20 [0.58;119.60] 5/-   102/- 107 -
ref
Total 2 studies 1.32 [0.49;3.54] 817 2,295
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 1.10[0.92; 1.30]7102,29588%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Pérez-Molina, 2002Pérez-Molina, 2002 5.20[0.58; 119.60]107-12%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 23% 1.32[0.49; 3.54]8172,2950.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.32[0.49; 3.54]8172,29523%NAFeldkamp, 2010 Pérez-Molina, 2002 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.32[0.49; 3.54]8172,29523%NAFeldkamp, 2010 Pérez-Molina, 2002 2 Tags Adjustment   - No  - No 5.20[0.36; 74.67]107- -NAPérez-Molina, 2002 1   - Yes  - Yes 1.10[0.93; 1.31]7102,295 -NAFeldkamp, 2010 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.32[0.49; 3.54]8172,29523%NAFeldkamp, 2010 Pérez-Molina, 2002 2 All studiesAll studies 1.32[0.49; 3.54]8172,29523%NAFeldkamp, 2010 Pérez-Molina, 2002 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.32[0.49; 3.54]8172,29523%NAFeldkamp, 2010 Pérez-Molina, 2002 20.510.01.0