Acetaminophen (Paracetamol) updated on 09-20-2024

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18501
R79023		 Feldkamp, 2010 Craniosynostosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.97 [0.79;1.18] 240/2,196   239/2,426 479 2,196
ref
S18505
R78765		 Rebordosa a, 2008 Craniosynostosis 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.21 [0.78;1.89] 33/26,424   64/61,718 97 26,424
ref
Total 2 studies 1.01 [0.84;1.21] 576 28,620
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 0.97[0.79; 1.18]4792,19683%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Rebordosa a, 2008Rebordosa a, 2008 1.21[0.78; 1.89]9726,42417%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.01[0.84; 1.21]57628,6200.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.78; 1.88]9726,424 -NARebordosa a, 2008 1 case control studiescase control studies 0.97[0.79; 1.19]4792,196 -NAFeldkamp, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.01[0.84; 1.21]57628,6200%NAFeldkamp, 2010 Rebordosa a, 2008 2 Tags Adjustment   - Yes  - Yes 1.01[0.84; 1.21]57628,6200%NAFeldkamp, 2010 Rebordosa a, 2008 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.97[0.79; 1.19]4792,196 -NAFeldkamp, 2010 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.21[0.78; 1.88]9726,424 -NARebordosa a, 2008 1 All studiesAll studies 1.01[0.84; 1.21]57628,6200%NAFeldkamp, 2010 Rebordosa a, 2008 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.01[0.84; 1.21]57628,6200%NAFeldkamp, 2010 Rebordosa a, 2008 20.510.01.0