Acetaminophen (Paracetamol) updated on 09-20-2024

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18501
R79021		 Feldkamp, 2010 Spina bifida 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.05 [0.85;1.30] 207/2,163   228/2,415 435 2,163
ref
S18505
R78739		 Rebordosa a, 2008 Spina bifida 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.50 [0.20;1.22] 7/26,424   31/61,718 38 26,424
ref
Total 2 studies 0.83 [0.42;1.63] 473 28,587
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 1.05[0.85; 1.30]4352,16368%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Rebordosa a, 2008Rebordosa a, 2008 0.50[0.20; 1.22]3826,42432%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 59% 0.83[0.42; 1.63]47328,5870.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.50[0.20; 1.23]3826,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.05[0.85; 1.30]4352,163 -NAFeldkamp, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.83[0.42; 1.63]47328,58759%NAFeldkamp, 2010 Rebordosa a, 2008 2 Tags Adjustment   - Yes  - Yes 0.83[0.42; 1.63]47328,58759%NAFeldkamp, 2010 Rebordosa a, 2008 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.05[0.85; 1.30]4352,163 -NAFeldkamp, 2010 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.50[0.20; 1.23]3826,424 -NARebordosa a, 2008 1 All studiesAll studies 0.83[0.42; 1.63]47328,58759%NAFeldkamp, 2010 Rebordosa a, 2008 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.83[0.42; 1.63]47328,58759%NAFeldkamp, 2010 Rebordosa a, 2008 20.510.01.0