Acetaminophen (Paracetamol) updated on 09-20-2024

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18519
R78693		 Kerr, 2019 Isolated microcephaly (ICD-9 - Within 6 months after delivery) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.94 [0.49;1.81] 19/4,625   38/7,491 57 4,625
ref
Total 1 studies 0.94 [0.49;1.81] 57 4,625
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kerr, 2019Kerr, 2019 0.94[0.49; 1.81]574,6250%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.94[0.49; 1.81]574,625 -NAKerr, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.49; 1.81]574,625 -NAKerr, 2019 1 Tags Adjustment   - Yes  - Yes 0.94[0.49; 1.81]574,625 -NAKerr, 2019 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.94[0.49; 1.81]574,625 -NAKerr, 2019 1 All studiesAll studies 0.94[0.49; 1.81]574,625 -NAKerr, 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.49; 1.81]574,625 -NAKerr, 2019 10.510.01.0