Acetaminophen (Paracetamol) updated on 09-20-2024

Congenital glaucoma

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18667
R79332
Cifuentes, 2025 Congenital glaucoma 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: prescription or medical files 2.29 [1.36;3.84] 15/4,521   336/218,476 351 4,521
ref
S18501
R79029
Feldkamp, 2010 Glaucoma 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.13 [0.66;1.92] 31/1,404   31/1,602 62 1,404
ref
Total 2 studies 1.61 [0.81;3.22] 413 5,925
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cifuentes, 2025Cifuentes, 2025 2.29[1.36; 3.84]3514,52150%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Feldkamp, 2010Feldkamp, 2010 1.13[0.66; 1.92]621,40450%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 71% 1.61[0.81; 3.22]4135,9250.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.61[0.81; 3.22]4135,92571%NACifuentes, 2025 Feldkamp, 2010 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.81; 3.22]4135,92571%NACifuentes, 2025 Feldkamp, 2010 2 Tags Adjustment   - No  - No 2.29[1.36; 3.85]3514,521 -NACifuentes, 2025 1   - Yes  - Yes 1.13[0.66; 1.93]621,404 -NAFeldkamp, 2010 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.13[0.66; 1.93]621,404 -NAFeldkamp, 2010 1   - prescription or medical files  - prescription or medical files 2.29[1.36; 3.85]3514,521 -NACifuentes, 2025 1 All studiesAll studies 1.61[0.81; 3.22]4135,92571%NACifuentes, 2025 Feldkamp, 2010 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.81; 3.22]4135,92571%NACifuentes, 2025 Feldkamp, 2010 20.510.01.0