Acetaminophen (Paracetamol) updated on 09-20-2024

Atresia or stenosis of other parts of small intestine

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18505
R78752		 Rebordosa a, 2008 Small intestinal atresia 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.79 [0.28;2.17] 6/26,424   18/61,718 24 26,424
ref
S18503
R78916		 Werler, 2002 Small intestinal atresia (atresia, stenosis, or webbing of the duodenum, jejunum, or ileum, without gastroschisis) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.00 [0.60;1.60] 55/377   71/547 126 377
ref
Total 2 studies 0.96 [0.61;1.49] 150 26,801
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa a, 2008Rebordosa a, 2008 0.79[0.28; 2.17]2426,42419%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Werler, 2002Werler, 2002 1.00[0.60; 1.60]12637781%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.96[0.61; 1.49]15026,8010.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.79[0.28; 2.20]2426,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.00[0.61; 1.63]126377 -NAWerler, 2002 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.61; 1.49]15026,8010%NARebordosa a, 2008 Werler, 2002 2 Tags Adjustment   - Yes  - Yes 0.96[0.61; 1.49]15026,8010%NARebordosa a, 2008 Werler, 2002 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.00[0.61; 1.63]126377 -NAWerler, 2002 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.79[0.28; 2.20]2426,424 -NARebordosa a, 2008 1 All studiesAll studies 0.96[0.61; 1.49]15026,8010%NARebordosa a, 2008 Werler, 2002 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.61; 1.49]15026,8010%NARebordosa a, 2008 Werler, 2002 20.510.01.0