Acetaminophen (Paracetamol) updated on 09-20-2024

Congenital constriction bands/amniotic band

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18513
R78665		 Zafeiri, 2022 Amniotic band defects during pregnancy (anytime or not specified) excluded retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.98 [0.63;1.52]
excluded (exposition period) 		29/24,099   90/107,143 119 24,099
ref
S18501
R79051		 Feldkamp, 2010 Amniotic bands 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.99 [0.66;1.47] 50/2,006   63/2,250 113 2,006
ref
S18566
R78943		 Werler, 2003 Amniotic Band Defects (that includes amnion rupture sequence (ARS) and body wall complex (BWC)) 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: maternal ITW/questionnaires after pregnancy 1.79 [1.12;2.87] C 59/7,007   25/5,304 84 7,007
ref
Total 2 studies 1.32 [0.74;2.35] 197 9,013
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 0.99[0.66; 1.47]1132,00652%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Werler, 2003Werler, 2003 1.79[1.12; 2.87]847,00748%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 72% 1.32[0.74; 2.35]1979,0130.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.32[0.74; 2.35]1979,01372%NAFeldkamp, 2010 Werler, 2003 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.32[0.74; 2.35]1979,01372%NAFeldkamp, 2010 Werler, 2003 2 Tags Adjustment   - No  - No 1.79[1.12; 2.87]847,007 -NAWerler, 2003 1   - Yes  - Yes 0.99[0.66; 1.48]1132,006 -NAFeldkamp, 2010 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.32[0.74; 2.35]1979,01372%NAFeldkamp, 2010 Werler, 2003 2 All studiesAll studies 1.32[0.74; 2.35]1979,01372%NAFeldkamp, 2010 Werler, 2003 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.32[0.74; 2.35]1979,01372%NAFeldkamp, 2010 Werler, 2003 20.510.01.0