Acetaminophen (Paracetamol) updated on 09-20-2024

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18496
R78610		 Xu, 2024 APGAR < 7 score at 1 min during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: prescription or medical files 3.28 [1.73;6.21] 47/501   20/501 67 501
ref
S18513
R78661		 Zafeiri, 2022 APGAR score at 1min < 7 during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.23 [1.18;1.28] 3,437/24,030   14,335/106,552 17,772 24,030
ref
Total 2 studies 1.90 [0.73;4.95] 17,839 24,531
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xu, 2024Xu, 2024 3.28[1.73; 6.21]6750144%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Zafeiri, 2022Zafeiri, 2022 1.23[1.18; 1.28]17,77224,03056%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 89% 1.90[0.73; 4.95]17,83924,5310.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.90[0.73; 4.95]17,83924,53189%NAXu, 2024 Zafeiri, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.90[0.73; 4.95]17,83924,53189%NAXu, 2024 Zafeiri, 2022 2 Tags Adjustment   - Yes  - Yes 1.90[0.73; 4.95]17,83924,53189%NAXu, 2024 Zafeiri, 2022 2 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.23[1.18; 1.28]17,77224,030 -NAZafeiri, 2022 1   - prescription or medical files  - prescription or medical files 3.28[1.73; 6.21]67501 -NAXu, 2024 1 All studiesAll studies 1.90[0.73; 4.95]17,83924,53189%NAXu, 2024 Zafeiri, 2022 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.90[0.73; 4.95]17,83924,53189%NAXu, 2024 Zafeiri, 2022 20.510.01.0