Acetaminophen (Paracetamol) updated on 09-20-2024

Leukemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18637
R79205		 Couto, 2015 Acute lymphocytic leukemia - Children aged 0–23 months 3 months (or more) before pregnancy or during pregnancy excluded case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.56 [0.28;1.10]
excluded (exposition period) 		17/77   74/259 91 77
ref
S18626
R79160		 Ognjanovic, 2011 Acute lymphoblastic leukaemia - After knowledge of pregnancy - Any use during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes Matched Paracetamol use: maternal ITW/questionnaires after pregnancy 1.03 [0.70;1.53] 181/407   80/174 261 407
ref
S18774
R79881		 Ross, 2003 Leukemia (<18 months of age) during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes Co-administration Matched Paracetamol use: maternal ITW/questionnaires after pregnancy Paracetamol use: prescription or medical files 1.11 [0.41;2.98] 8/19   235/617 243 19
ref
Total 2 studies 1.04 [0.72;1.50] 504 426
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ognjanovic, 2011Ognjanovic, 2011 1.03[0.70; 1.53]26140787%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Ross, 2003Ross, 2003 1.11[0.41; 2.98]2431913%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.04[0.72; 1.50]5044260.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 2 Tags Adjustment   - Yes  - Yes 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 2 Co-administrationCo-administration 1.11[0.41; 2.99]24319 -NARoss, 2003 1 MatchedMatched 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 2   - prescription or medical files  - prescription or medical files 1.11[0.41; 2.99]24319 -NARoss, 2003 1 All studiesAll studies 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.72; 1.50]5044260%NAOgnjanovic, 2011 Ross, 2003 20.510.01.0