Acetaminophen (Paracetamol) updated on 09-20-2024

Infant allergies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18575
R78924		 Li, 2021 Atopic dermatitis diagnoses (ICD-9-CM code: 691.8) - Age about 10 years old during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Paracetamol use: prescription or medical files 1.12 [1.00;1.26] 1,818/5,252   711/2,335 2,529 5,252
ref
S18568
R78919		 Jedrychowski, 2011 Infantile eczema (child experienced dry skin in combination with itchy rash and typical localization, which was confirmed by physician) - In the first five years of life during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.20 [0.81;1.77] -/73   -/249 - 73
ref
S18638
R79213		 Koniman, 2007 Allergic asthma (asthma and positive skin prick test) - Between 3 and 10 yr of age during pregnancy (anytime or not specified) case control sibling Adjustment: No Matched Paracetamol use: maternal ITW/questionnaires after pregnancy 20.43 [1.04;401.69] C 6/6   11/28 17 6
ref
Total 3 studies 1.18 [0.86;1.63] 2,546 5,331
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Li, 2021Li, 2021 1.12[1.00; 1.26]2,5295,25265%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Jedrychowski, 2011Jedrychowski, 2011 1.20[0.81; 1.77]-7334%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: unclear Koniman, 2007Koniman, 2007 20.43[1.04; 401.69]1761%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical Total (3 studies) I2 = 47% 1.18[0.86; 1.63]2,5465,3310.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.81; 1.77]-73 -NAJedrychowski, 2011 1 case control studiescase control studies 3.22[0.21; 49.65]2,5465,25873%NALi, 2021 Koniman, 2007 2 RCTRCT 20.43[1.04; 401.69]176 -NAKoniman, 2007 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.13[1.01; 1.26]2,5295,3250%NALi, 2021 Jedrychowski, 2011 2 sibling designsibling design 20.43[1.04; 401.69]176 -NAKoniman, 2007 1 Tags Adjustment   - No  - No 20.43[1.04; 401.69]176 -NAKoniman, 2007 1   - Yes  - Yes 1.13[1.01; 1.26]2,5295,3250%NALi, 2021 Jedrychowski, 2011 2 MatchedMatched 3.22[0.21; 49.65]2,5465,25873%NALi, 2021 Koniman, 2007 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 20.43[1.04; 401.69]176 -NAKoniman, 2007 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.20[0.81; 1.77]-73 -NAJedrychowski, 2011 1   - prescription or medical files  - prescription or medical files 1.12[1.00; 1.26]2,5295,252 -NALi, 2021 1 All studiesAll studies 1.18[0.86; 1.63]2,5465,33147%NALi, 2021 Jedrychowski, 2011 Koniman, 2007 30.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[1.01; 1.26]2,5295,3250%NALi, 2021 Jedrychowski, 2011 2 siblingssiblings Out of scale20.43[1.04; 401.69]176 -NAKoniman, 2007 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Xiao (Eczema in children)Xiao (Eczema in children) 1.31[0.97; 1.76]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 Xiao (Eczema in children (Adjusted studies))Xiao (Eczema in children (Adjusted studies)) 1.23[0.72; 2.09]48%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.18[0.86; 1.63]47%5,331----Li, 2021 Jedrychowski, 2011 Koniman, 2007 30.510.01.0