Acetaminophen (Paracetamol) updated on 09-20-2024

Child/Infant weight abnormalities (>= 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18522
R78711		 Liew_Boys, 2019 Overweight at age 11 (overweight and obesity according to the International Obesity Task Force reference) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.03 [0.92;1.16] 658/6,730   465/5,754 1,123 6,730
ref
S18521
R78701		 Liew_Girls, 2019 Overweight at age 11 (overweight and obesity according to the International Obesity Task Force reference) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.10 [0.97;1.24] 660/6,951   404/5,499 1,064 6,951
ref
Total 2 studies 1.06 [0.98;1.16] 2,187 13,681
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liew_Boys, 2019Liew_Boys, 2019 1.03[0.92; 1.16]1,1236,73053%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Liew_Girls, 2019Liew_Girls, 2019 1.10[0.97; 1.24]1,0646,95147%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.06[0.98; 1.16]2,18713,6810.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 2 Tags Adjustment   - Yes  - Yes 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 2 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 2 All studiesAll studies 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.98; 1.16]2,18713,6810%NALiew_Boys, 2019 Liew_Girls, 2019 20.510.01.0