| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S16660 R70014 |
Woodbury a, 2024 | Expressive vocabulary score (≤25th percentile) - MacArthur-Bates Communicative Development Inventories (CDI) Parent's report - Average age of 27.42 (±1.08) months | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.00 [0.99;1.01] | -/208 -/90 | - | 208 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16657 R69971 |
Bertoldi_Pelotas, 2020 | Cognitive development (Language) - INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) - Mean (SD) 2.0 (0.06) years (Acetaminophen 1st, 2nd, or 3rd trim) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: No extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.00 [0.89;1.13] | -/2,470 -/1,348 | - | 2,470 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16648 R69902 |
Tovo-Rodrigues, 2020 | Communication area (< 10th percentile) - Battelle's Developmental Inventory - At 24 months | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy | 1.04 [0.84;1.30] | -/- -/- | - | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16654 R69944 |
Tronnes, 2020 | Communication problems (T scores ≥65) - The Ages and Stages Questionnaire (ASQ), Parents completed - At 5 years (use in three trimesters) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.18 [0.86;1.60] | 149/1,757 1,281/17,317 | 1,430 | 1,757 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16642 R69844 |
Liew a, 2016 | Verbal IQ - Wechsler Primary and Preschool Scales of intelligence-revised (WPPSi-r) - 5 years old | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.08 [0.90;1.31] | -/881 -/610 | - | 881 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 5 studies | 1.00 [0.99;1.01] | 1,430 | 5,316 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Asymetry test p-value = 0.1102 (by Egger's regression)
slope=0.0000 (0.0028); intercept=0.5568 (0.2477); t=2.2477; p=0.1102
excluded