| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18555 R78893 |
Okubo (Controls unexposed, general population), 2025 | Autism spectrum disorder (ASD) - ICD-10 codes (F84 - diagnoses only) - Mean follow up 4.4 years | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: prescription or medical files | 1.07 [0.98;1.15] | -/42,123 -/42,123 | - | 42,123 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18556 R78900 |
Okubo (Controls unexposed, sibling), 2025 | Autism spectrum disorder (ASD) - ICD-10 codes (diagnoses only) - Mean follow up 4.4 years | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | sibling excluded | Adjustment: Yes Control group: Sibling Paracetamol use: prescription or medical files |
0.85 [0.64;1.13] excluded (control group) |
-/11,696 -/11,897 | - | 11,696 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16629 R69725 |
Ahlqvist (Population-Based), 2024 | Autism - ICD-10 (F84) or ICD-9 (299) - Median (IQR) follow-up of 13.4 (7.6-19.8) years | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.05 [1.02;1.08] | 5,912/185,909 62,672/2,294,888 | 68,584 | 185,909 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16630 R69731 |
Ahlqvist (Sibling), 2024 | Autism - ICD-10 (F84) or ICD-9 (299) - Median (IQR) follow-up of 13.4 (7.6-19.8) years | during pregnancy (anytime or not specified) | population based cohort retrospective | sibling excluded | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy |
0.98 [0.93;1.04] excluded (control group) |
3,956/- 41,294/- | 45,250 | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16643 R69862 |
Liew b, 2016 | Autism Spectrum Disorder diagnosis (ICD-10 F84.0-F84.9) - Follow-up 11-17 years old (average 12.7 years) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.19 [1.04;1.35] | 626/36,187 401/28,135 | 1,027 | 36,187 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 1.07 [1.02;1.13] | 69,611 | 264,219 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, general population; 2: Population-Based;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 16630, 18556