Acetaminophen (Paracetamol) updated on 09-20-2024

Child/infant digestive auto-immune diseases (Crohn, Coeliac disease , …)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18631
R79172		 Marild, 2017 Celiac Disease Diagnosis (minimum 2 registrations of the ICD-10 code K90.0) or Celiac Disease reported by parental questionnaires administered when the child is 7 to 8 years - Median follow up: 8.5 years (at least > 5 years) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.11 [0.94;1.31] 305/39,117   312/45,157 617 39,117
ref
Total 1 studies 1.11 [0.94;1.31] 617 39,117
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marild, 2017Marild, 2017 1.11[0.94; 1.31]61739,1170%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 1 Tags Adjustment   - Yes  - Yes 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 1 All studiesAll studies 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.94; 1.31]61739,117 -NAMarild, 2017 10.510.01.0