Acetaminophen (Paracetamol) updated on 09-20-2024

Child/infant diabetes Type 1

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18569
R78920		 Tapia, 2018 Type 1 diabetes (ICD-10 diagnosis E10) - Median age 12.3 years (range 8. –17.9) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.22 [0.97;1.53] 171/-   -/- - -
ref
Total 1 studies 1.22 [0.97;1.53] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tapia, 2018Tapia, 2018 1.22[0.97; 1.53]--0%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.97; 1.53]-- -NATapia, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.22[0.97; 1.53]-- -NATapia, 2018 1 Tags Adjustment   - Yes  - Yes 1.22[0.97; 1.53]-- -NATapia, 2018 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.22[0.97; 1.53]-- -NATapia, 2018 1 All studiesAll studies 1.22[0.97; 1.53]-- -NATapia, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.97; 1.53]162- -NATapia, 2018 10.510.01.0