Acetaminophen (Paracetamol) updated on 09-20-2024

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18505
R78738		 Rebordosa a, 2008 Nervous system malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.79 [0.54;1.17] 36/26,424   115/61,718 151 26,424
ref
S18773
R79880		 Winship, 1984 Central nervous system (CNS) defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: prescription or medical files 1.05 [0.53;2.06] 21/41   743/1,487 764 41
ref
Total 2 studies 0.85 [0.61;1.19] 915 26,465
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa a, 2008Rebordosa a, 2008 0.79[0.54; 1.17]15126,42476%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Winship, 1984Winship, 1984 1.05[0.53; 2.06]7644124%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 0.85[0.61; 1.19]91526,4650.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.79[0.54; 1.16]15126,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.05[0.53; 2.07]76441 -NAWinship, 1984 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.85[0.61; 1.19]91526,4650%NARebordosa a, 2008 Winship, 1984 2 Tags Adjustment   - No  - No 1.05[0.53; 2.07]76441 -NAWinship, 1984 1   - Yes  - Yes 0.79[0.54; 1.16]15126,424 -NARebordosa a, 2008 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.79[0.54; 1.16]15126,424 -NARebordosa a, 2008 1   - prescription or medical files  - prescription or medical files 1.05[0.53; 2.07]76441 -NAWinship, 1984 1 All studiesAll studies 0.85[0.61; 1.19]91526,4650%NARebordosa a, 2008 Winship, 1984 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.85[0.61; 1.19]91526,4650%NARebordosa a, 2008 Winship, 1984 20.510.01.0