Acetaminophen (Paracetamol) updated on 09-20-2024

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18667
R79330		 Cifuentes, 2025 Congenital ocular anomalies (Anophthalmia, Microphthalmia, Congenital Glaucoma, Congenital Cataract, Colobomas, ...) 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: prescription or medical files 1.47 [1.22;1.77] 118/4,624   4,067/232,279 4,185 4,624
ref
S18505
R78740		 Rebordosa a, 2008 Eye malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.95 [0.62;1.47] 32/26,424   75/61,718 107 26,424
ref
Total 2 studies 1.24 [0.81;1.88] 4,292 31,048
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cifuentes, 2025Cifuentes, 2025 1.47[1.22; 1.77]4,1854,62460%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Rebordosa a, 2008Rebordosa a, 2008 0.95[0.62; 1.47]10726,42440%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 70% 1.24[0.81; 1.88]4,29231,0480.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.62; 1.46]10726,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.47[1.22; 1.77]4,1854,624 -NACifuentes, 2025 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.24[0.81; 1.88]4,29231,04870%NACifuentes, 2025 Rebordosa a, 2008 2 Tags Adjustment   - No  - No 1.47[1.22; 1.77]4,1854,624 -NACifuentes, 2025 1   - Yes  - Yes 0.95[0.62; 1.46]10726,424 -NARebordosa a, 2008 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.95[0.62; 1.46]10726,424 -NARebordosa a, 2008 1   - prescription or medical files  - prescription or medical files 1.47[1.22; 1.77]4,1854,624 -NACifuentes, 2025 1 All studiesAll studies 1.24[0.81; 1.88]4,29231,04870%NACifuentes, 2025 Rebordosa a, 2008 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.24[0.81; 1.88]4,29231,04870%NACifuentes, 2025 Rebordosa a, 2008 20.510.01.0