Acetaminophen (Paracetamol) updated on 09-20-2024

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18505
R78744		 Rebordosa a, 2008 Heart malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.00 [0.86;1.17] 259/26,424   611/61,718 870 26,424
ref
S18771
R79875		 Källén, 2003 Any cardiovascular defect (except with chromosome anomaly) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.08 [0.97;1.21] 332/36,626   -/577,730 - 36,626
ref
S18780
R79905		 Zierler, 1985 Any severe congenital heart disease (cardiac catheterization or surgery or death within the first year of life) 1st trimester case control unexposed (general population or NOS) Adjustment: No Paracetamol use: maternal ITW/questionnaires after pregnancy Paracetamol use: prescription or medical files 1.06 [0.79;1.44] C 84/283   214/753 298 283
ref
Total 3 studies 1.05 [0.97;1.15] 1,168 63,333
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa a, 2008Rebordosa a, 2008 1.00[0.86; 1.17]87026,42431%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Källén, 2003Källén, 2003 1.08[0.97; 1.21]-36,62661%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Zierler, 1985Zierler, 1985 1.06[0.79; 1.44]2982838%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.05[0.97; 1.15]1,16863,3330.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.96; 1.15]87063,0500%NARebordosa a, 2008 Källén, 2003 2 case control studiescase control studies 1.06[0.79; 1.44]298283 -NAZierler, 1985 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.97; 1.15]1,16863,3330%NARebordosa a, 2008 Källén, 2003 Zierler, 1985 3 Tags Adjustment   - No  - No 1.06[0.79; 1.44]298283 -NAZierler, 1985 1   - Yes  - Yes 1.05[0.96; 1.15]87063,0500%NARebordosa a, 2008 Källén, 2003 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.06[0.79; 1.44]298283 -NAZierler, 1985 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.05[0.96; 1.15]87063,0500%NARebordosa a, 2008 Källén, 2003 2   - prescription or medical files  - prescription or medical files 1.06[0.79; 1.44]298283 -NAZierler, 1985 1 All studiesAll studies 1.05[0.97; 1.15]1,16863,3330%NARebordosa a, 2008 Källén, 2003 Zierler, 1985 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.05[0.97; 1.15]1,49163,3330%NARebordosa a, 2008 Källén, 2003 Zierler, 1985 30.510.01.0