Acetaminophen (Paracetamol) - Medication and Pregnancy KB

Acetaminophen (Paracetamol) updated on 09-20-2024

Respiratory system anomalies

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18507 R78642	Broe (Controls unexposed, general pop), 2025	Respiratory malformations	1st trimester	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Paracetamol use: prescription or medical files	1.93 [1.12;3.32] excluded (control group)	14/8,590 358/471,855	372	8,590		ref
S18508 R78643	Broe (Controls unexposed, sick), 2025	Respiratory malformations	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes Paracetamol use: prescription or medical files	2.32 [1.03;5.24]	14/8,590 10/14,817	24	8,590		ref
S18505 R78747	Rebordosa a, 2008	Respiratory malformations	1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.06 [0.66;1.68]	29/26,424 62/61,718	91	26,424		ref
					Total	2 studies	1.46 [0.69;3.10]		115	35,014
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18507